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Effexor Withdrawal. Effexor side effects, Effexor withdrawal side effects, Effexor stories and Effexor solutions. Effexor withdrawal.  Effexor withdrawal. How to safely withdrawal off Effexor.

Brand name (Effexor)

Effexor Withdrawal Solution, Side Effects, Treatment Options

Effexor Withdrawal Symptoms

The majority of people attempting Effexor withdrawal experience an  antidepressant withdrawal syndrome. This is also known as Effexor discontinuation syndrome in the United States. In Europe it is call Effexor withdrawal side effects. The F.D.A. estimates 10% of those experiencing Effexor withdrawal will go back up on the Effexor because the withdrawal symptoms are too severe.

The most common and debilitating Effexor withdrawal side effect is called "brain zaps."  Brain zaps are described by people experiencing it as a; electrical jolt that tends to run from base of the neck up into their head. Another side effect that tends to run with brain zaps is a shiver, a feeling as your head is floating, dizziness, and/or a whirling sensation in the head.

These symptoms can come in waves or even be persistent.

The good news; in 2002, our founder, Jim Harper, discovered the correct type of Omega 3 taken in the right quantity will eliminate these devastating head symptoms quickly. Usually within a couple of hours.

The body in a normal state uses the oil from our diet, specifically from omega 3 found in fish, to build and replenish the end point of areas in the brain that sends and receives electrical signals. We are using easy to understand  terminology here so it is easy to understand. Let's leave the technical jargon to physicians.

These brain zaps have nothing to do with serotonin levels or other made up reasons. It is simple really; our body works in a very natural way with how it uses amino acids, proteins, fats in food and all other diet items to maintain a balance. When you introduce any toxin that disrupts these processes the body reacts.

The most common Effexor withdrawal symptoms reported include:

Flu like symptoms



Brain zaps




Increased suicidal ideation





Ringing in the ears




Mood swings

Please note: These are the most common Effexor withdrawal side effects but far from all potential Effexor withdrawal side effects.

There is a warning the FDA has put a black box warning on Effexor.

See full prescribing information for complete boxed warning.
· Antidepressants increased the risk of suicidal thoughts and behaviors
in pediatric and young adult patients (5.1)
· Closely monitor for clinical worsening and emergence of suicidal
thoughts and behaviors

You may have been prescribed  Effexor within a very short doctor visit. There was no investigation into other life factors, lab testing, or any conversation about what side effects might present. The failings of this approach may cause quite a burden on the patient.

Depression, insomnia, anxiety, fibromyalgia, and other symptoms that Effexor is often prescribed for might stem from; diminished vitamin D levels, over active JNK gene, specific proteins that need to be silenced, dietary concerns and food allergies, mitochondrial dysfunction, neurotoxic accumulation, and many other reasons. A full physical from an understanding physician is ideal, before prescribing Effexor.

Do Your Symptoms Require Effexor?

The Road Back Program uses nutritional supplements to help with the Effexor withdrawal. Most people feel a very fast relief from the Effexor withdrawal once they begin taking the supplements and we feel the odds are high; if would have taken nutritional supplements like these before starting the Effexor you would have been prescribed the Effexor in the first place.

In 2007, Jim Harper was giving a speech to a group of psychiatrists in Ireland and during his talk he mentioned his mother just passed away 30 days ago. He went on to describe how he made sure to take his JNK Formula each day to help the body cope with the stress being put on it do to his loss. He went on to say, "The JNK Formula will not remove the emotional loss and how I feel but it will keep the body strong during my time to grieve."

How Do You Survive Effexor Withdrawal?

Surviving Effexor withdrawal depends on what you do at this very moment. If you keep doing the same thing you have been doing and you are in a heavy Effexor withdrawal, nothing will change for the positive, That is a given.

If you decide to do the Effexor withdrawal as an inpatient in a drug rehab center DO NOT DO THE 9 DAY PLAN BECAUSE THAT WHAT INSURANCE ALLOWS. Over the past 22 years I have worked with far to many people who were sold on a rehab facility, stayed the 9 days because insurance would only pay for that amount of time. The unscrupulous facility took them off the Effexor in 9 days as they promised and by the time the person got off the airplane after their return home they were in full withdrawal. You can't do a Effexor withdrawal in 9 days.

The Road Back Program can normally help you get back on your feet again but the rehab facility approach of this type is not worth the price you will pay mentally and physically.  

You will find a few other outpatient Effexor withdrawal programs on the internet now and Jim Harper is not aware of one that will cause you harm like the rehab facility's mentioned. However, every other program on the internet was trained by Jim Harper years ago and they are doing what Jim Harper and The Road Back did during that time frame. Almost 2 decades ago Jim Harper trained several physicians and good intentioned people how to get a patient off Effexor. Jim went in to detail of the process and what nutritional supplements were used and why they were used. At that time of The Road Back the success rate was not as high as desired and over the following years Jim changed the formulas used with the supplements several times to use new information with DNA testing. Long story short; you will likely wind up using a Effexor withdrawal approach The Road Back used in 2003, that was scrapped for something more successful.

If you are currently in Effexor withdrawal, send Jim Harper an email and he will personally guide you through the process so you can get back on your feet quickly and have a very successful Effexor withdrawal.

It does not matter if you have been on Effexor for 1 month or 20 years. Recovery can happen and the good part is; it does not take more time because you have been taking Effexor for years.

When Do Effexor Withdrawal Symptoms Start When Discontinuing / Quitting Effexor?

Effexor withdrawal usually begins between day 1 and day 3 of adjusting the Effexor. For some people this is not the case but eventually most everyone hits some dosage of the Effexor when reducing that jars them. Effexor withdrawal begins and they have no idea what they should do. Their physician does not know what to do. They wind up in a spiral downward and wind up on a new medication to try and stop the Effexor withdrawal. The best case is the additional drug does that but you are now on 2 drugs instead of only Effexor.

What is Effexor?

This SSRI drug is prescribed in treating adult depressive disorders (MDD), panic disorder, obsessive compulsory disorders (OCD), social anxiety (SAD), post-traumatic stress disorders (PTSD), and premenstrual dysphoric disorder (PMDD).

If you have anxiety before taking Effexor, or anxiety begins while taking Effexor, odds are the anxiety will continue to get worse. Effexor alters dopamine much like the antidepressant Effexor and anxiety is a byproduct of these two drugs.

What Is Effexor Used For?

Effexor is an antidepressant medication approved to treat adult MDD (major depressive disorder). The Black Box warning on the drug’s packaging mentions that the drug should not be prescribed to anyone under the age of 25, due to heightened risk of suicide. There is an exception to this for patients under the age of 25 who have been diagnosed with OCD (obsessive-compulsive disorder).

Potential suicidality is associated with all Effexor and may be a concern leading to consider Effexor withdrawal, which is recommended to be done always under medical or caregiver monitoring.

Adult-only approved uses for the drug provided in a clinical or treatment setting include:

  • MDD:  Major Depressive Disorder<
  • PTSD:  Post-traumatic stress disorder
  • PD:  Panic disorder
  • SAD:  Social anxiety disorder
  • OCD:  Obsessive-compulsive disorder
  • PMDD:  Premenstrual dysphoric disorder

Effexor Side Effects

The full list of Effexor side effects is quite staggering. In 2004, Jim Harper used the Freedom of Information Act to get the full list of Effexor side effects. Jim received the information and it is 500 sheets of letter size paper, single space, a number 10 font size, 3 columns per page. In other words, thousands of known potential Effexor side effects were disclosed.

Some of the other Effexor and Effexor withdrawal side effects:

  • Serotonin syndrome: A life-threatening condition requiring immediate medical care in a hospital emergency clinic or ICU. Symptoms to watch for include sudden fever, losing consciousness, inability to move or speak, copious sweating, dilated pupils, chills, tremors, convulsions, diarrhea, agitation, restlessness, racing heart, etc.
  • Suicidal thoughts (common)
  • Suicide attempt (common)
  • Hyperkinesis (muscle spasms, movement disorder)
  • Worsened depression
  • Aggression
  • Paranoia (rare)
  • Anxiety
  • Mania (common)
  • Convulsions
  • Unconsciousness
  • Coma
  • Teeth grinding
  • Akathisia (relentless internal restlessness and discomfort marked by repeated motions, pacing, rocking, etc., that can lead to suicidal thoughts as a means of relief)
  • Tachycardia (racing heart, even when the body is at rest)
  • Rash
  • Itching
  • Burning, crawling feeling in the skin
  • Fever
  • Tics, sudden jerky movements, myoclonus
  • Emotional blunting
  • Behavioral apathy, SSRI-induced-indifference
  • Pain on urination or difficulty urinating
  • Cloudy urine
  • Headache
  • Sexual impairments, i.e., anorgasmia, inability to ejaculate, lowered libido
  • Mood swings
  • Pain around the eyes or eye sockets
  • Sleepiness
  • Bladder pain
  • Prickling skin sensation
  • Numbness
  • Sensory disturbances
  • Insomnia
  • Depersonalization (common)
  • Nervousness
  • Nightmares (paroniria)
  • Hostility
  • Nausea
  • Diarrhea
  • Weight gain

Some documented Effexor birth defects and injuries include:

  • PPHN or persistent pulmonary hypertension of the newborn, a heart and lung condition which can result in respiratory failure, decreased oxygen to the brain, and multiple organ injuries.
  • Congenital Heart Defects connected to Effexor and other SSRIs include ventricular septal defects and atrial septal defects, also referred to as “holes in the heart”, related to heart murmurs, suppressed appetite, breathing difficulties, tiredness, inadequate growth, etc.
  • Increased Risk of Autism has been extensively reported but evidence has not yet been considered conclusive enough for regulatory bodies to ban prescribing to pregnant women.
  • Increased Risk of Clubfoot connected to SSRIs during pregnancy as reported by NIMH, where exposure had the highest increase in clubfoot of all SSRIs.
  • Increased risk of atrial/ventricular defects and craniosynostosis was reported in a Canadian study from 1998 to 2010 and published in the June 2015 issue of the American Journal of Gynecology & Obstetrics.

Effexor Withdrawal, What to Expect

If using The Road Back Program you should expect to feel a lot better within the first couple days of the program. If you do nothing, expect to continue to feel as you do now. Possibly worse as time goes on. The chance of feeling better if you do nothing is nil.

In 1999, The Road Back only had people taper the Effexor gradually and slowly. They still suffered. Around 50% could get off the Effexor but most went back on the Effexor because they continual Effexor withdrawal side effects would not diminish or go away.

We wish there was a better answer for you than the above but with working with over 19 million people over the last 22 years, the truth is the truth. No way to water it down to make it sound better.

Some may think it is just their depression returning but who would not feel depressed if they were still going through Effexor withdrawal months after stopping the Effexor.

We can't stress enough; what you do or do not do at this moment in time is critical for your future. Take your time if at all possible. If you have brain zaps go buy any omega 3 fish oil, even the wrong omega 3 fish oil will help somewhat.

While you read this you may want to pause and go take a walk. Look at the trees, the sky or anything off in the distance. Getting your attention off your mind and body may do wonders.

Keep this close to your heart; There is Hope and There is a Solution. We are speaking directly to YOU.

A 30 day supply of the nutritional supplements will cost you around $80. If you feel it is worth $80 to take a chance that all of this can go away in a couple of days, then take that chance. Over the past 22 years many have sent an email to Jim Harper and said they were not sure what to do about the Effexor withdrawal. Even after reading this information. The people that tried something else generally came back within a few months and were in worse shape than before. We do not want this to happen to you. But if is; Jim will still be here to assist.

Can Effexor Make Depression Worse?

Common sense answers this question. If depression is one side effect of taking Effexor then Effexor can cause depression. You do stand a greater chance of Effexor causing depression during withdrawal than while simply taking the Effexor as prescribed. The depression during Effexor withdrawal can be due to the other Effexor withdrawal side effects you are experiencing. Who would not start to get depressed if you have anxiety from morning to night, can't sleep and your head feels like it is on fire.

Effexor Aggression in Children

Children are more prone to aggression when taking Effexor than adults.  It occurs in 10-20% of children taking any SSRI antidepressant. Two clinical trials performed by Pfizer, aggression was the most common reason noted for Effexor discontinuation.

Can You Get Addicted to Effexor?

Yes and no. This is where Effexor dependence is a matter of wording. Medically speaking in the United States Effexor is not addicting. In Europe it is viewed as addicting. The bottom line is; Once you take Effexor for 7 days the Effexor has made its way through your body. If your body no longer has the Effexor in its system, your body will react to the Effexor being gone.

Much like a person that eats a lot a sweets every day. Your body will react when the sweet substance is not present. Call it addicting, as we would, call it a dependence as United States physicians will, it is what it is. If you do not provide the substance the body reacts and you also have mental feelings that are not positive. We can get into the insulin discussion etc, but we are only talking about a substance being present and then not and the body and mind reacting in a negative manner.

What is the difference between Effexor and a Benzodiazepine?

Effexor is an SSRI medication, an antidepressant, used to treat depression and anxiety. Benzodiazepines are prescribed mainly for the treatment of anxiety and panic disorders but also prescribed off-label to treat depression.

These two types drug have different chemical components and were designed to work on different brain receptors and neurotransmitters, but some of their effects can be seen to overlap.  Benzodiazepines are thought to mainly affect GABA transmission, which can slow the central nervous system to reduce anxiety, while Effexor is designed to block the reuptake of serotonin.

Benzodiazepines are known to be more prone to dependence/addiction than Effexor. While the withdrawal symptoms are similar between both drugs, Effexor’s half-life is 22-36 hours, and Benzodiazepines half-life is much lower. Benzodiazepines can have more severe complications if abruptly stopped, including seizures.  For safe Benzodiazepine or Effexor withdrawal, either of these drugs must be slowly tapered to allow the central nervous system and neurochemistry to safely normalize.

Choosing to withdrawal from the Effexor first or the benzodiazepine first needs to be evaluated. Use Chapter 23, The Science to decide is part of that equation. Depending on the benzodiazepine you may be taking with the Effexor, if you reduce the Effexor first it may make you go into withdrawal on the benzodiazepine, even if you did not reduce the benzodiazepine.

How long does Effexor stay in your system after the last dosage?

Our founder, Jim Harper, made great strides with determining this question. Using his DNA testing company in 2004-2005, Jim conducted hundreds of DNA tests to determine how fast or slow medications took to metabolize. In roughly 34 percent of the population the Effexor can take as long as 48 hours to clear the body. In others, as little as 8 hours can occur for the Effexor to clear the body.  

Depending on other habits you may have, Effexor could clear faster or even take more time than the 48 hours. If you smoke cigarettes and stop smoking while taking Effexor, the Effexor dosage you are taking will decrease by 15%. On the other side of this, if you start smoking  while taking Effexor, the Effexor dosage will act as though it is 15% higher than you think it is. This is because cigarettes induce an enzyme  used to metabolize Effexor and anything using that same pathway will shoot though much faster. Caffeine restricts that same enzyme, so if you start or stop drinking coffee while taking Effexor you will either go into withdrawal or feel an overdose, even though you have not changed the Effexor dosage.

This is why The Road Back Program wants you to not change smoking habits or caffeine habits during the Effexor taper.

Can you overdose on Effexor?

Yes, it is definitely possible for Effexor poisoning to occur. A substantial Effexor overdose requires emergency medical intervention to prevent major health problems. This list of Effexor overdose symptoms would be the same as those Effexor side effects listed above, but more severe.

According to the National Institute of Health (NIH), the use of intravenous benzodiazepines is sometimes required during Effexor overdose to prevent seizures. Extra cooling measures must be used to reduce hyperthermia, always under the direction of EMT or other medical staff attending to the patient.

Treatment for Effexor Withdrawal

Effexor has become one of the most frequently prescribed antidepressants in the US. Of equal importance is that depressive disorders have become one of the most frequently diagnosed conditions. These two facts together underscore two important steps toward improved health:

  • Providing safe treatment programs for those who have decided on Effexor withdrawal, and
  • Offering drug-free options to regain natural mental health without the need for prescription medications.

The Road Back Program was described by Dr. Hyla Cass M.D. in this way:

Here's an essential handbook on how to safely and more easily wean yourself
(under medical supervision) off the heavily over-prescribed psychotropic medications. I have used the program with my patients and it works!"
Hyla Cass M.D. Author of Supplement Your Prescription

Send an email to Jim Harper by using the Contact link on the top of this page or read How to Get Off Psychoactive Drugs Safely by Jim Harper and follow the program for Effexor withdrawal. Why Jim put his entire book on our website for free is so you can instantly read the material and start this process if you are ready now.

One last thing Jim asked us to provide at the bottom of each page of Effexor descriptions:

There is Hope and There is a Solution


Clinical Studies

Association between CYP2C19 polymorphism and depressive symptoms.

Sim SC, Nordin L, Andersson TM, Virding S, Olsson M, Pedersen NL, Ingelman-Sundberg M.

Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 7. [Epub ahead of print]Effexor: 20468063 [Effexor - as supplied by publisher]Related Effexor Citations

[Diagnosis of epilepsy complicated by panic disorder and a non-specific reaction to a ssri.]

Wanders AJ, de Leeuw AS, van Megen HJ.

Tijdschr Psychiatr. 2010;52(5):349-52. Dutch. Effexor: 20458682 [Effexor - in process]Free Effexor ArticleRelated Effexor Citations

Influence of citalopram on interdigestive gastrointestinal motility in man.

Janssen P, Vos R, Tack J.

Aliment Pharmacol Ther. 2010 May 8. [Epub ahead of print]Effexor: 20456311 [Effexor - as supplied by publisher]Related Effexor Citations

A randomized controlled trial of antidepressant continuation for major depression following traumatic brain injury.

Rapoport MJ, Mitchell RA, McCullagh S, Herrmann N, Chan F, Kiss A, Feinstein A, Lanctôt KL.

J Clin Psychiatry. 2010 Apr 20. [Epub ahead of print]Effexor: 20441723 [Effexor - as supplied by publisher]Related Effexor Citations

Variation in the risk of suicide attempts and completed suicides by antidepressant agent in adults: a propensity score-adjusted analysis of 9 years' data.

Schneeweiss S, Patrick AR, Solomon DH, Mehta J, Dormuth C, Miller M, Lee JC, Wang PS.

Arch Gen Psychiatry. 2010 May;67(5):497-506.Effexor: 20439831 [Effexor - indexed for MEDLINE]Related Effexor Citations

Toxicity of antidepressants: rates of suicide relative to prescribing and non-fatal overdose.

Hawton K, Bergen H, Simkin S, Cooper J, Waters K, Gunnell D, Kapur N.

Br J Psychiatry. 2010 May;196(5):354-8.Effexor: 20435959 [Effexor - in process]Related Effexor Citations

Medial prefrontal cortex activity during memory encoding of pictures and its relation to symptomatic improvement after citalopram treatment in patients with major depression.

Roy M, Harvey PO, Berlim MT, Mamdani F, Beaulieu MM, Turecki G, Lepage M.

J Psychiatry Neurosci. 2010 May;35(3):152-62.Effexor: 20420766 [Effexor - in process]Free PMC ArticleFree textRelated Effexor Citations

Differential effects of serotonergic and noradrenergic antidepressants on brain activity during a cognitive control task and neurofunctional prediction of treatment outcome in patients with depression.

Wagner G, Koch K, Schachtzabel C, Sobanski T, Reichenbach JR, Sauer H, Schlösser RG.

J Psychiatry Neurosci. 2010 May 1. doi: 10.1503/jpn.090081. [Epub ahead of print]Effexor: 20420762 [Effexor - as supplied by publisher]Free Effexor ArticleRelated Effexor Citations


Berardelli R, Margarito E, Ghiggia F, Picu A, Balbo M, Bonelli L, Giordano R, Karamouzis I, Bo M, Ghigo E, Arvat E.

J Endocrinol Invest. 2010 Apr 22. [Epub ahead of print]Effexor: 20414043 [Effexor - as supplied by publisher]Related Effexor Citations

Nationwide drug-dispensing data reveal important differences in adherence to drug label recommendations on CYP2D6-dependent drug interactions.

Mannheimer B, Wettermark B, Lundberg M, Pettersson H, von Bahr C, Eliasson E.

Br J Clin Pharmacol. 2010 Apr;69(4):411-7.Effexor: 20406225 [Effexor - in process]Related Effexor Citations

The effect of the NMDA receptor antagonist dizocilpine on behavioral manifestations of serotonin and adrenergic antidepressants in rats.

Pruus K, Rudissaar R, Allikmets L, Harro J.

Methods Find Exp Clin Pharmacol. 2010 Mar;32(2):123-8.Effexor: 20401349 [Effexor - in process]Related Effexor Citations

The role of the serotoninergic system in the regulation of thyroid function in old rats.

Masalova OO, Sapronov NS.

Bull Exp Biol Med. 2009 Nov;148(5):815-8.Effexor: 20396800 [Effexor - in process]Related Effexor Citations

Antidepressant-Induced Sexual Dysfunction among Newer Antidepressants in a Naturalistic Setting.

Lee KU, Lee YM, Nam JM, Lee HK, Kweon YS, Lee CT, Jun TY.

Psychiatry Investig. 2010 Mar;7(1):55-9. Epub 2010 Feb 8.Effexor: 20396434 [Effexor - in process]Free PMC ArticleFree textRelated Effexor Citations

Comparative safety of antidepressant agents for children and adolescents regarding suicidal acts.

Schneeweiss S, Patrick AR, Solomon DH, Dormuth CR, Miller M, Mehta J, Lee JC, Wang PS.

Pediatrics. 2010 May;125(5):876-88. Epub 2010 Apr 12.Effexor: 20385637 [Effexor - indexed for MEDLINE]Related Effexor Citations

Citalopram (antidepressant) administration causes sexual dysfunction in male mice through RF-amide related peptide in the dorsomedial hypothalamus.

Soga T, Wong DW, Clarke IJ, Parhar IS.

Neuropharmacology. 2010 Apr 8. [Epub ahead of print]Effexor: 20381503 [Effexor - as supplied by publisher]Related Effexor Citations

Prescription patterns of antidepressants: findings from a US claims database.

Milea D, Verpillat P, Guelfucci F, Toumi M, Lamure M.

Curr Med Res Opin. 2010 Jun;26(6):1343-53.Effexor: 20373875 [Effexor - in process]Related Effexor Citations

Aripiprazole Improves Depressive Symptoms and Immunological Response to Antiretroviral Therapy in an HIV-Infected Subject with Resistant Depression.

Cecchelli C, Grassi G, Pallanti S.

Case Report Med. 2010;2010:836214. Epub 2010 Mar 30.Effexor: 20369069 [Effexor - in process]Free PMC ArticleFree textRelated Effexor Citations

Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.

Binder EB, Owens MJ, Liu W, Deveau TC, Rush AJ, Trivedi MH, Fava M, Bradley B, Ressler KJ, Nemeroff CB.

Arch Gen Psychiatry. 2010 Apr;67(4):369-79.Effexor: 20368512 [Effexor - indexed for MEDLINE]Related Effexor Citations

High rates of sustained virological response in hepatitis C virus-infected injection drug users receiving directly observed therapy with peginterferon alpha-2a (40KD) (PEGASYS) and once-daily ribavirin.

Waizmann M, Ackermann G.

J Subst Abuse Treat. 2010 Jun;38(4):338-45. Epub 2010 Apr 1.Effexor: 20362408 [Effexor - in process]Related Effexor Citations

Multi-residue analysis of pharmaceutical compounds in wastewaters by dual solid-phase microextraction coupled to liquid chromatography electrospray ionization ion trap mass spectrometry.

Unceta N, Sampedro MC, Abu Bakar NK, Gómez-Caballero A, Goicolea MA, Barrio RJ.

J Chromatogr A. 2010 May 14;1217(20):3392-9. Epub 2010 Mar 15.Effexor: 20362295 [Effexor - in process]Related Effexor Citations

Augmentation with citalopram for suicidal ideation in middle-aged and older outpatients with schizophrenia and schizoaffective disorder who have subthreshold depressive symptoms: a randomized controlled trial.

Zisook S, Kasckow JW, Lanouette NM, Golshan S, Fellows I, Vahia I, Mohamed S, Rao S.

J Clin Psychiatry. 2010 Mar 9. [Epub ahead of print]Effexor: 20361918 [Effexor - as supplied by publisher]Related Effexor Citations

Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.

Uher R, Perroud N, Ng MY, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Zagar T, Czerski PM, Jerman B, Larsen ER, Schulze TG, Zobel A, Cohen-Woods S, Pirlo K, Butler AW, Muglia P, Barnes MR, Lathrop M, Farmer A, Breen G, Aitchison KJ, Craig I, Lewis CM, McGuffin P.

Am J Psychiatry. 2010 May;167(5):555-64. Epub 2010 Apr 1.Effexor: 20360315 [Effexor - indexed for MEDLINE]Related Effexor Citations

Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test.

Andreasen JT, Nielsen EO, Christensen JK, Olsen GM, Peters D, Mirza NR, Redrobe JP.

J Psychopharmacol. 2010 Apr 1. [Epub ahead of print]Effexor: 20360159 [Effexor - as supplied by publisher]Related Effexor Citations

A highly sensitive LC-MS/MS method for the determination of S-citalopram in rat plasma: application to a pharmacokinetic study in rats.

Suresh PS, Giri S, Husain R, Mullangi R.

Biomed Chromatogr. 2010 Mar 29. [Epub ahead of print]Effexor: 20352615 [Effexor - as supplied by publisher]Related Effexor Citations

Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents.

Paterson NE, Fedolak A, Olivier B, Hanania T, Ghavami A, Caldarone B.

Pharmacol Biochem Behav. 2010 Jun;95(4):449-56. Epub 2010 Mar 25.Effexor: 20346966 [Effexor - in process]Related Effexor Citations

Efficacy and safety of escitalopram versus citalopram in major depressive disorder: a 6-week, multicenter, randomized, double-blind, flexible-dose study.

Ou JJ, Xun GL, Wu RR, Li LH, Fang MS, Zhang HG, Xie SP, Shi JG, Du B, Yuan XQ, Zhao JP.

Psychopharmacology (Berl). 2010 Mar 26. [Epub ahead of print]Effexor: 20340011 [Effexor - as supplied by publisher]Related Effexor Citations

Removal of pharmaceutical and personal care products (PPCPs) under nitrifying and denitrifying conditions.

Suarez S, Lema JM, Omil F.

Water Res. 2010 May;44(10):3214-24. Epub 2010 Mar 6.Effexor: 20338614 [Effexor - in process]Related Effexor Citations

Glycogen: a novel branched polysaccharide chiral selector in CE.

Chen J, Du Y, Zhu F, Chen B.

Electrophoresis. 2010 Mar;31(6):1044-50.Effexor: 20309915 [Effexor - in process]Related Effexor Citations

Human lymphoblastoid cell line panels: novel tools for assessing shared drug pathways.

Morag A, Kirchheiner J, Rehavi M, Gurwitz D.

Pharmacogenomics. 2010 Mar;11(3):327-40.Effexor: 20235789 [Effexor - in process]Related Effexor Citations

Open channel block of Kv1.5 currents by citalopram.

Lee HM, Hahn SJ, Choi BH.

Acta Pharmacol Sin. 2010 Apr;31(4):429-35. Epub 2010 Mar 15.Effexor: 20228830 [Effexor - in process]Related Effexor Citations

Are typical starting doses of the selective serotonin reuptake inhibitors sub-optimal? A meta-analysis of randomized, double-blind, placebo-controlled, dose-finding studies in major depressive disorder.

Papakostas GI, Charles D, Fava M.

World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):300-7.Effexor: 20218793 [Effexor - in process]Related Effexor Citations

Melatonin inhibits serotonin transporter activity in intestinal epithelial cells.

Matheus N, Mendoza C, Iceta R, Mesonero JE, Alcalde AI.

J Pineal Res. 2010 May;48(4):332-9. Epub 2010 Mar 4.Effexor: 20210852 [Effexor - in process]Related Effexor Citations

Salvage use of citalopram for treatment of fluoxetine-resistant premature ejaculation in recently married men: a prospective clinical trial.

Dadfar MR, Baghinia MR.

Urol J. 2010 Winter;7(1):40-4.Effexor: 20209455 [Effexor - in process]Free Effexor ArticleRelated Effexor Citations

[Citalopram hepatotoxicity.]

Rubio Merino MI, Arranz Carrero A, Alvarez García JF, Antón Martínez J.

Med Clin (Barc). 2010 Mar 4. [Epub ahead of print] Spanish. No abstract available. Effexor: 20206946 [Effexor - as supplied by publisher]Related Effexor Citations


Mischo M, Nigg C, Kiss A.

Praxis (Bern 1994). 2010 Mar 3;99(5):271-6; quiz 277-8. Review. German. No abstract available. Effexor: 20205083 [Effexor - indexed for MEDLINE]Related Effexor Citations

Aripiprazole as adjunct to a mood stabilizer and citalopram in bipolar depression: a randomized placebo-controlled pilot study.

Quante A, Zeugmann S, Luborzewski A, Schommer N, Langosch J, Born C, Anghelescu I, Wolf J.

Hum Psychopharmacol. 2010 Mar;25(2):126-32.Effexor: 20196183 [Effexor - in process]Related Effexor Citations

Validity of the Definite and Semidefinite Questionnaire version of the Hamilton Depression Scale, the Hamilton Subscale and the Melancholia Scale. Part I.

Bent-Hansen J, Bech P.

Eur Arch Psychiatry Clin Neurosci. 2010 Mar 2. [Epub ahead of print]Effexor: 20195869 [Effexor - as supplied by publisher]Related Effexor Citations

Increases in serotonergic neuronal activity following intracerebroventricular administration of AF64A in rats.

Park SH, Lim DK.

Arch Pharm Res. 2010 Feb;33(2):301-8. Epub 2010 Feb 24.Effexor: 20195832 [Effexor - in process]Related Effexor Citations

Citalopram enhances cocaine's subjective effects in rats.

Soto PL, Hiranita T, Katz JL.

Behav Pharmacol. 2009 Dec;20(8):759-62.Effexor: 20195220 [Effexor - in process]Related Effexor Citations

Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder.

Garriock HA, Tanowitz M, Kraft JB, Dang VC, Peters EJ, Jenkins GD, Reinalda MS, McGrath PJ, von Zastrow M, Slager SL, Hamilton SP.

Am J Psychiatry. 2010 May;167(5):565-73. Epub 2010 Mar 1.Effexor: 20194481 [Effexor - indexed for MEDLINE]Related Effexor Citations

Pharmacologically induced/exacerbated restless legs syndrome, periodic limb movements of sleep, and REM behavior disorder/REM sleep without atonia: literature review, qualitative scoring, and comparative analysis.

Hoque R, Chesson AL Jr.

J Clin Sleep Med. 2010 Feb 15;6(1):79-83. Review.Effexor: 20191944 [Effexor - indexed for MEDLINE]Related Effexor Citations

Sex differences in the serotonergic influence on the hypothalamic-pituitary-adrenal stress axis.

Goel N, Bale TL.

Endocrinology. 2010 Apr;151(4):1784-94. Epub 2010 Feb 25.Effexor: 20185764 [Effexor - indexed for MEDLINE]Related Effexor Citations

Efficacy and tolerability of antidepressants for treatment of depression in coronary artery disease: a meta-analysis.

Dowlati Y, Herrmann N, Swardfager WL, Reim EK, Lanctôt KL.

Can J Psychiatry. 2010 Feb;55(2):91-9.Effexor: 20181304 [Effexor - in process]Related Effexor Citations

Impact and clinical management of depression in patients with coronary artery disease.

Summers KM, Martin KE, Watson K.

Pharmacotherapy. 2010 Mar;30(3):304-22.Effexor: 20180613 [Effexor - in process]Related Effexor Citations

fMRI tracks reductions in repetitive behaviors in autism: Two case studies.

Dichter GS, Sikich L, Mahorney S, Felder JN, Lam KS, Turner-Brown L, Bodfish J.

Neurocase. 2010 Feb 22:1-10. [Epub ahead of print]Effexor: 20178033 [Effexor - as supplied by publisher]Related Effexor Citations

Deaths involving serotonergic drugs.

Pilgrim JL, Gerostamoulos D, Drummer OH.

Forensic Sci Int. 2010 May 20;198(1-3):110-7. Epub 2010 Feb 20.Effexor: 20172668 [Effexor - in process]Related Effexor Citations

Inhibitory and facilitory actions of isocyanine derivatives at human and rat organic cation transporters 1, 2 and 3: a comparison to human alpha1- and alpha2-adrenoceptor subtypes.

Amphoux A, Millan MJ, Cordi A, Bönisch H, Vialou V, Mannoury la Cour C, Dupuis DS, Giros B, Gautron S.

Eur J Pharmacol. 2010 May 25;634(1-3):1-9. Epub 2010 Feb 17.Effexor: 20170649 [Effexor - in process]Related Effexor Citations

Escitalopram causes fewer seizures in human overdose than citalopram.

Yilmaz Z, Ceschi A, Rauber-Lüthy C, Sauer O, Stedtler U, Prasa D, Seidel C, Hackl E, Hoffmann-Walbeck P, Gerber-Zupan G, Bauer K, Kupferschmidt H, Kullak-Ublick GA, Wilks M.

Clin Toxicol (Phila). 2010 Mar;48(3):207-12.Effexor: 20170390 [Effexor - indexed for MEDLINE]Related Effexor Citations

Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats.

Piper BJ, Ali SF, Daniels LG, Meyer JS.

Synapse. 2010 Jun;64(6):421-31.Effexor: 20169574 [Effexor - in process]Related Effexor Citations

Antidepressant drugs for chronic urological pelvic pain: an evidence-based review.

Papandreou C, Skapinakis P, Giannakis D, Sofikitis N, Mavreas V.

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Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat.

Lucas G, Du J, Romeas T, Mnie-Filali O, Haddjeri N, Piñeyro G, Debonnel G.

PLoS One. 2010 Feb 16;5(2):e9253.Effexor: 20169084 [Effexor - in process]Free PMC ArticleFree textRelated Effexor Citations

Estradiol valerate elicits antidepressant-like effects in middle-aged female rats under chronic mild stress.

Romano-Torres M, Fernández-Guasti A.

Behav Pharmacol. 2010 Mar;21(2):104-11.Effexor: 20168212 [Effexor - in process]Related Effexor Citations

Anxiolytic-like property of risperidone and olanzapine as examined in multiple measures of fear in rats.

Sun T, He W, Hu G, Li M.

Pharmacol Biochem Behav. 2010 May;95(3):298-307. Epub 2010 Feb 16.Effexor: 20167232 [Effexor - in process]Related Effexor Citations

Citalopram not effective for repetitive behaviour in autistic spectrum disorders.

Myers SM.

Evid Based Ment Health. 2010 Feb;13(1):22. No abstract available. Effexor: 20164519 [Effexor]Related Effexor Citations

Is escitalopram really relevantly superior to citalopram in treatment of major depressive disorder? A meta-analysis of head-to-head randomized trials.

Trkulja V.

Croat Med J. 2010 Feb;51(1):61-73.Effexor: 20162747 [Effexor - in process]Free PMC ArticleFree textRelated Effexor Citations

Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.

Field JR, Henry LK, Blakely RD.

J Biol Chem. 2010 Apr 9;285(15):11270-80. Epub 2010 Feb 16.Effexor: 20159976 [Effexor - indexed for MEDLINE]Related Effexor Citations

Prinzmetal-variant angina in a patient using zolmitriptan and citalopram.

Acikel S, Dogan M, Sari M, Kilic H, Akdemir R.

Am J Emerg Med. 2010 Feb;28(2):257.e3-6.Effexor: 20159412 [Effexor - indexed for MEDLINE]Related Effexor Citations

[Personality test and prediction of antidepressive treatment effect in mental illness]

Thorleifsson A, Holst K, Diaz M, Folker H.

Ugeskr Laeger. 2010 Feb 15;172(7):539-44. Danish. Effexor: 20156404 [Effexor - indexed for MEDLINE]Related Effexor Citations

Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen.

Lash TL, Cronin-Fenton D, Ahern TP, Rosenberg CL, Lunetta KL, Silliman RA, Hamilton-Dutoit S, Garne JP, Ewertz M, Sørensen HT, Pedersen L.

Acta Oncol. 2010 Apr;49(3):305-12.Effexor: 20156115 [Effexor - in process]Related Effexor Citations

Baseline neurocognitive profiles differentiate abstainers and non-abstainers in a cocaine clinical trial.

Schmitz JM, Mooney ME, Green CE, Lane SD, Steinberg JL, Swann AC, Moeller FG.

J Addict Dis. 2009 Jul;28(3):250-7.Effexor: 20155594 [Effexor - in process]Related Effexor Citations

A cognitive deficit induced in rats by chronic intermittent cold stress is reversed by chronic antidepressant treatment.

Danet M, Lapiz-Bluhm S, Morilak DA.

Int J Neuropsychopharmacol. 2010 Feb 11:1-13. [Epub ahead of print]Effexor: 20149267 [Effexor - as supplied by publisher]Related Effexor Citations

Escitalopram--translating molecular properties into clinical benefit: reviewing the evidence in major depression.

Leonard B, Taylor D.

J Psychopharmacol. 2010 Mar 16. [Epub ahead of print]Effexor: 20147575 [Effexor - as supplied by publisher]Related Effexor Citations


Trento M, Kucich C, Tibaldi P, Borgo E, Gennari S, Tedesco S, Balbo M, Arvat E, Cavallo F, Ghigo E, Porta M.

J Endocrinol Invest. 2010 Feb 5. [Epub ahead of print]Effexor: 20142635 [Effexor - as supplied by publisher]Related Effexor Citations

Serotonin modulates glutamatergic transmission in the rat olfactory tubercle.

Hadley JK, Halliwell JV.

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The relationship between antidepressant use and smoking cessation in pregnant women in treatment for substance abuse.

Chisolm MS, Brigham EP, Tuten M, Strain EC, Jones HE.

Am J Drug Alcohol Abuse. 2010 Jan;36(1):46-51.Effexor: 20141396 [Effexor - indexed for MEDLINE]Related Effexor Citations

Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study.

Martinez C, Assimes TL, Mines D, Dell'aniello S, Suissa S.

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Antidepressants in functional dyspepsia.

Talley NJ, Herrick L, Locke GR.

Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):5-8. No abstract available. Effexor: 20136584 [Effexor - indexed for MEDLINE]Free Effexor ArticleRelated Effexor Citations

Evaluation of the enantioseparation capability of the novel chiral selector clindamycin phosphate towards basic drugs by micellar electrokinetic chromatography.

Chen B, Du Y.

J Chromatogr A. 2010 Mar 12;1217(11):1806-12. Epub 2010 Jan 21.Effexor: 20132938 [Effexor - indexed for MEDLINE]Related Effexor Citations

Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors.

Sacre S, Medghalchi M, Gregory B, Brennan F, Williams R.

Arthritis Rheum. 2010 Mar;62(3):683-93.Effexor: 20131240 [Effexor - indexed for MEDLINE]Related Effexor Citations

Clinical trials in CNS--SMi's eighth annual conference.

Kirk R.

IDrugs. 2010 Feb;13(2):66-9.Effexor: 20127552 [Effexor - indexed for MEDLINE]Related Effexor Citations

Escitalopram and enhancement of cognitive recovery following stroke.

Jorge RE, Acion L, Moser D, Adams HP Jr, Robinson RG.

Arch Gen Psychiatry. 2010 Feb;67(2):187-96.Effexor: 20124118 [Effexor - indexed for MEDLINE]Related Effexor Citations

Aging impairs the antidepressant-like response to citalopram in male rats.

Herrera-Pérez JJ, Martínez-Mota L, Fernández-Guasti A.

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A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice.

Böer U, Noll C, Cierny I, Krause D, Hiemke C, Knepel W.

Eur J Pharmacol. 2010 May 10;633(1-3):33-8. Epub 2010 Feb 1.Effexor: 20122921 [Effexor - in process]Related Effexor Citations

Antidepressant pharmaceuticals in two U.S. effluent-impacted streams: occurrence and fate in water and sediment, and selective uptake in fish neural tissue.

Schultz MM, Furlong ET, Kolpin DW, Werner SL, Schoenfuss HL, Barber LB, Blazer VS, Norris DO, Vajda AM.

Environ Sci Technol. 2010 Mar 15;44(6):1918-25.Effexor: 20121081 [Effexor - in process]Related Effexor Citations

Simultaneous determination of citalopram and its metabolite in human plasma by LC-MS/MS applied to pharmacokinetic study.

Jiang T, Rong Z, Peng L, Chen B, Xie Y, Chen C, Sun J, Xu Y, Lu Y, Chen H.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Feb 15;878(5-6):615-9. Epub 2010 Jan 14.Effexor: 20116349 [Effexor - indexed for MEDLINE]Related Effexor Citations

In response to van Gorp F. et al. Escitalopram overdose.

Lugassy DM, Hoffman RS, Chessex N.

Ann Emerg Med. 2010 Jan;55(1):128-9; author reply 129-30. No abstract available. Effexor: 20116020 [Effexor - indexed for MEDLINE]Related Effexor Citations

The impact of diabetes on depression treatment outcomes.

Bryan C, Songer T, Brooks MM, Rush AJ, Thase ME, Gaynes B, Balasubramani GK, Trivedi MH, Fava M, Wisniewski SR.

Gen Hosp Psychiatry. 2010 Jan-Feb;32(1):33-41. Epub 2009 Aug 27.Effexor: 20114126 [Effexor - indexed for MEDLINE]Related Effexor Citations

Serotonin modulates sensitivity to reward and negative feedback in a probabilistic reversal learning task in rats.

Bari A, Theobald DE, Caprioli D, Mar AC, Aidoo-Micah A, Dalley JW, Robbins TW.

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Combining motivational interviewing with compliance enhancement therapy (MI-CET): development and preliminary evaluation of a new, manual-guided psychosocial adjunct to alcohol-dependence pharmacotherapy.

Heffner JL, Tran GQ, Johnson CS, Barrett SW, Blom TJ, Thompson RD, Anthenelli RM.

J Stud Alcohol Drugs. 2010 Jan;71(1):61-70.Effexor: 20105415 [Effexor - in process]Related Effexor Citations

[Discontinuation of antidepressant serotonergic antidepressant]

Andersen CL, Videbech P.

Ugeskr Laeger. 2010 Jan 25;172(4):296-8. Danish. Effexor: 20105399 [Effexor - indexed for MEDLINE]Related Effexor Citations

Improving depression and enhancing resilience in family dementia caregivers: a pilot randomized placebo-controlled trial of escitalopram.

Lavretsky H, Siddarth P, Irwin MR.

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Antidepressant medication and executive dysfunction: a deleterious interaction in late-life depression.

Sneed JR, Culang ME, Keilp JG, Rutherford BR, Devanand DP, Roose SP.

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Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats.

Buhl ES, Jensen TK, Jessen N, Elfving B, Buhl CS, Kristiansen SB, Pold R, Solskov L, Schmitz O, Wegener G, Lund S, Petersen KF.

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The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior.

Sarkisyan G, Roberts AJ, Hedlund PB.

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Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET.

Marner L, Gillings N, Madsen K, Erritzoe D, Baaré WF, Svarer C, Hasselbalch SG, Knudsen GM.

Neuroimage. 2010 Apr 15;50(3):855-61. Epub 2010 Jan 22.Effexor: 20096787 [Effexor - in process]Related Effexor Citations

Serotonergic neurons mediate ectopic release of dopamine induced by L-DOPA in a rat model of Parkinson's disease.

Navailles S, Bioulac B, Gross C, De Deurwaerdère P.

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The B-VITAGE trial: a randomized trial of homocysteine lowering treatment of depression in later life.

Ford AH, Flicker L, McCaul K, van Bockxmeer F, Hegarty S, Hirani V, Fenner S, Almeida OP.

Trials. 2010 Jan 25;11:8.Effexor: 20096138 [Effexor - indexed for MEDLINE]Free PMC ArticleFree textRelated Effexor Citations

Relationship of residual mood and panic-agoraphobic spectrum phenomenology to quality of life and functional impairment in patients with major depression.

Benvenuti A, Rucci P, Calugi S, Cassano GB, Miniati M, Frank E.

Int Clin Psychopharmacol. 2010 Mar;25(2):68-74.Effexor: 20061961 [Effexor - indexed for MEDLINE]Related Effexor Citations

Changes in 5-HT4 receptor and 5-HT transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice.

Licht CL, Kirkegaard L, Zueger M, Chourbaji S, Gass P, Aznar S, Knudsen GM.

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The identification of inhibitors of Schistosoma mansoni miracidial transformation by incorporating a medium-throughput small-molecule screen.

Taft AS, Norante FA, Yoshino TP.

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Changes in antidepressant metabolism in pregnancy evidenced by metabolic ratios in hair: a novel approach.

O'Brien L, Baumer C, Thieme D, Sachs H, Koren G.

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The two enantiomers of citalopram bind to the human serotonin transporter in reversed orientations.

Koldsø H, Severinsen K, Tran TT, Celik L, Jensen HH, Wiborg O, Schiøtt B, Sinning S.

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Diagnostic crossover from obesity to atypical anorexia nervosa - a case report.

Wolter H, Schneider N, Pfeiffer E, Lehmkuhl U.

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Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB.

Laje G, Cannon DM, Allen AS, Klaver JM, Peck SA, Liu X, Manji HK, Drevets WC, McMahon FJ.

Int J Neuropsychopharmacol. 2010 Jan 5:1-10. [Epub ahead of print]Effexor: 20047709 [Effexor - as supplied by publisher]Related Effexor Citations

Involvement of serotonin neurotransmission in hippocampal neurogenesis and behavioral responses in a rat model of post-stroke depression.

Wang SH, Zhang ZJ, Guo YJ, Sui YX, Sun Y.

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Excessive daytime somnolence in spinocerebellar ataxia type 1.

Dang D, Cunnington D.

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Alpha1-adrenoceptors modulate citalopram-induced serotonin release.

Rea K, Folgering J, Westerink BH, Cremers TI.

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Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the rapid simultaneous quantification of aconitine, mesaconitine, and hypaconitine in rat plasma after oral administration of Sini decoction.

He LP, Di B, Du YX, Yan F, Su MX, Liu HQ, You LJ.

J Anal Toxicol. 2009 Nov-Dec;33(9):588-94.Effexor: 20040133 [Effexor - indexed for MEDLINE]Related Effexor Citations

Notch1 signaling related hippocampal neurogenesis in adult poststroke depression rats: a valid index for an efficient combined citalopram and WAY100635 pharmacotherapy.

Wang SH, Zhang ZJ, Guo YJ, Sui YX, Sun Y.

Behav Pharmacol. 2010 Feb;21(1):47-57.Effexor: 20038834 [Effexor - indexed for MEDLINE]Related Effexor Citations

Diminished neural processing of aversive and rewarding stimuli during selective serotonin reuptake inhibitor treatment.

McCabe C, Mishor Z, Cowen PJ, Harmer CJ.

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