HOME
MEDICATIONS
PROGRAM SUPPLEMENTS
ABOUT US CONTACT
HOME
MEDICATIONS
PROGRAM SUPPLEMENTS
ABOUT US CONTACT
If you
want to taper off the Trintellix and you are not sure where to start, you can
click here and read the bestselling book, How to Get
Off Psychoactive Drugs Safely or send Jim Harper an email at
Jim@theroadback.org and he will guide you through the process of Trintellix
withdrawal.
If You
Are Already In Trintellix Withdrawal click here
If you
are experiencing brain zaps, electrical jolts in the head,
click here
Trintellix, also known as vortioxetine, is a medication used to treat major
depressive disorder. It is classified as a selective serotonin reuptake
inhibitor (SSRI) and is approved by the FDA for use in adults. While Trintellix
is generally well-tolerated, some people may experience withdrawal symptoms when
discontinuing the medication.
Withdrawal symptoms can occur when a person stops taking a medication abruptly
or reduces the dosage too quickly. Symptoms can vary in intensity and duration
depending on the individual and their level of dependence on the medication.
Trintellix withdrawal symptoms may include:
Dizziness or lightheadedness
Nausea
or vomiting
Headache
Anxiety or nervousness
Insomnia or sleep disturbances
Irritability or agitation
Flu-like symptoms such as fatigue, muscle aches, and sweating
Electric shock sensations, also known as brain zaps
Trintellix withdrawal
Trintellix Withdrawal
Trintellix Withdrawal
It is
important to note that not everyone will experience withdrawal symptoms when
stopping Trintellix, and some people may have a more severe experience than
others.
To
minimize the risk of withdrawal symptoms, it is important to follow the
recommended dosing instructions when taking Trintellix. If a person decides to
stop taking the medication, they should work with their healthcare provider to
gradually taper off the medication over a period of several weeks or months.
This gradual approach can help minimize the risk of withdrawal symptoms and
allow the body to adjust to the changes in medication.
If a
person does experience withdrawal symptoms, they should contact their healthcare
provider for advice and support. In some cases, the healthcare provider may
recommend restarting the medication and tapering off more slowly.
In
conclusion, Trintellix withdrawal symptoms can occur when a person stops taking
the medication or reduces the dosage too quickly. Symptoms can vary in intensity
and duration depending on the individual and their level of dependence on the
medication. To minimize the risk of withdrawal symptoms, it is important to
follow the recommended dosing instructions and work with a healthcare provider
to gradually taper off the medication. If a person does experience withdrawal
symptoms, they should seek medical advice and support.
While
Trintellix is generally well-tolerated, there have been some concerns about its
negative effects on the JNK gene.
The
JNK (c-Jun N-terminal kinase) gene is a protein that is involved in a variety of
cellular processes, including inflammation and cell death. In recent years,
there has been increasing interest in the role of JNK in the development of
depression and other mood disorders. Some studies have suggested that JNK may be
overactive in people with depression, and that this overactivity may contribute
to the symptoms of the condition.
There
is some evidence to suggest that Trintellix may have negative effects on the JNK
gene. Specifically, some studies have found that Trintellix can activate JNK and
increase its activity in certain brain regions. This activation may contribute
to the development of certain side effects associated with the medication, such
as nausea and vomiting.
While
the exact mechanisms underlying the relationship between Trintellix and JNK are
not fully understood, it is thought that the medication may interfere with the
normal regulation of JNK activity in the brain. This interference could
potentially lead to the overactivation of JNK and the development of negative
side effects.
Trintellix Withdrawal Solution, Side Effects, Treatment Options
Trintellix Withdrawal Symptoms
The
majority of people attempting Trintellix withdrawal experience antidepressant
withdrawal syndrome. This is also known as Trintellix discontinuation syndrome
in the United States. In Europe it is call Trintellix withdrawal side effects.
The F.D.A. estimates 10% of those experiencing Trintellix withdrawal will go
back up on the Trintellix because the withdrawal symptoms are too severe.
The
most common and debilitating Trintellix withdrawal side effect is called "brain
zaps." Brain zaps are described by people experiencing it as an electrical jolt
that tends to run from base of the neck up into their head. Another side effect
that tends to run with brain zaps is a shiver, a feeling as your head is
floating, dizziness, and/or a whirling sensation in the head.
These
symptoms can come in waves or even be persistent.
The
good news; in 2002, our founder, Jim Harper, discovered the correct type of
Omega 3 taken in the right quantity will eliminate these devastating head
symptoms quickly. Usually within a couple of hours.
The
body in a normal state uses the oil from our diet, specifically from omega 3
found in fish, to build and replenish the end point of areas in the brain that
sends and receives electrical signals.
We are
using easy to understand terminology here so it is easy to understand. Let's
leave the technical jargon to physicians. These brain zaps have nothing to do
with serotonin levels or other made up reasons. It is simple really; our body
works in a very natural way with how it uses amino acids, proteins, fats in food
and all other diet items to maintain a balance.
When
you introduce any toxin that disrupts these processes the body reacts. The most
common Trintellix withdrawal symptoms reported include:
Flu
like symptoms
Insomnia
Anxiety
Brain
zaps
Tremors
Diarrhea
Vomiting
Increased suicidal ideation
Nausea
Headache
Mania
Hypomania
Ringing in the ears
Aggression
Confusion
Imbalance
Mood
swings
Please
note: These are the most common Trintellix withdrawal side effects but far from
all potential Trintellix withdrawal side effects.
There
is a warning the FDA has put a black box warning on Trintellix. WARNING:
SUICIDAL THOUGHTS AND BEHAVIORS
See
full prescribing information for complete boxed warning.
Antidepressants increased the risk of suicidal thoughts and behaviors
in
pediatric and young adult patients (5.1) Closely monitor for clinical worsening
and emergence of suicidal thoughts and behaviors
You
may have been prescribed Trintellix within a very short doctor visit. There was
no investigation into other life factors, lab testing, or any conversation about
what side effects might present. The failings of this approach may cause quite a
burden on the patient.
Depression, insomnia, anxiety, fibromyalgia, and other symptoms that Trintellix
is often prescribed for might stem from; diminished vitamin D levels, over
active JNK gene, specific proteins that need to be silenced, dietary concerns
and food allergies, mitochondrial dysfunction, neurotoxic accumulation, and many
other reasons.
A full
physical from an understanding physician is ideal, before prescribing
Trintellix.
Do
Your Symptoms Require Trintellix?
The
Road Back Program uses nutritional supplements to help with the Trintellix
withdrawal. Most people feel a very fast relief from the Trintellix withdrawal
once they begin taking the supplements and we feel the odds are high; if you
would have taken nutritional supplements like these before starting the
Trintellix you would not have been prescribed the Trintellix in the first place.
"How
Do You Survive Trintellix Withdrawal?
Surviving Trintellix withdrawal depends on what you do at this very moment. If
you keep doing the same thing you have been doing and you are in a heavy
Trintellix withdrawal, nothing will change for the positive, That is a given.
If you
decide to do the Trintellix withdrawal as an inpatient in a drug rehab center DO
NOT DO THE 9 DAY PLAN BECAUSE THAT WHAT INSURANCE ALLOWS. Over the past 22 years
I have worked with far to many people who were sold on a rehab facility, stayed
the 9 days because insurance would only pay for that amount of time. The
unscrupulous facility took them off the Trintellix in 9 days as they promised
and by the time the person got off the airplane after their return home they
were in full withdrawal. You can't do a Trintellix withdrawal in 9 days.
The
Road Back Program can normally help you get back on your feet again but the
rehab facility approach of this type is not worth the price you will pay
mentally and physically.
You
will find a few other outpatient Trintellix withdrawal programs on the internet
now and Jim Harper is not aware of one that will cause you harm like the rehab
facility's mentioned. However, every other program on the internet was trained
by Jim Harper years ago and they are doing what Jim Harper and The Road Back did
during that time frame. Almost 2 decades ago Jim Harper trained several
physicians and good intentioned people how to get a patient off antidepressants.
Jim went in to detail of the process and what nutritional supplements were used
and why they were used. At that time of The Road Back the success rate was not
as high as desired and over the following years Jim changed the formulas used
with the supplements several times to use new information with DNA testing.
Long
story short; you will likely wind up using a Trintellix withdrawal approach The
Road Back used in 2003, that was scrapped for something more successful. If you
are currently in Trintellix withdrawal, send Jim Harper an email and he will
personally guide you through the process so you can get back on your feet
quickly and have a very successful Trintellix withdrawal.
It
does not matter if you have been on Trintellix for 1 month years. Recovery can
happen and the good part is; it does not take more time because you have been
taking Trintellix for years.
When
Do Trintellix Withdrawal Symptoms Start When Discontinuing / Quitting
Trintellix?
Trintellix withdrawal usually begins between day 1 and day 3 of adjusting the
Trintellix. For some people this is not the case but eventually most everyone
hits some dosage of the Trintellix when reducing that jars them. Trintellix
withdrawal begins and they have no idea what they should do. Their physician
does not know what to do. They wind up in a spiral downward and wind up on a new
medication to try and stop the Trintellix withdrawal.
The
best case is the additional drug does that but you are now on 2 drugs instead of
only Trintellix.
What
is Trintellix?
This
SSRI drug is prescribed in treating adult depressive disorders (MDD), panic
disorder, obsessive compulsory disorders (OCD), social anxiety (SAD),
post-traumatic stress disorders (PTSD), and premenstrual dysphoric disorder
(PMDD).If you have anxiety before taking Trintellix, or anxiety begins while
taking Trintellix, odds are the anxiety will continue to get worse. Trintellix
alters dopamine and anxiety is a byproduct of these two drugs.
Trintellix Withdrawal, What to Expect
If
using The Road Back Program you should expect to feel a lot better within the
first couple days of the program. If you do nothing, expect to continue to feel
as you do now. Possibly worse as time goes on. The chance of feeling better if
you do nothing is nil.
In
1999, The Road Back only had people taper the antidepressants gradually and
slowly. They still suffered. Around 50% could get off the Trintellix but most
went back on the Trintellix because they continual Trintellix withdrawal side
effects would not diminish or go away.
We
wish there was a better answer for you than the above but with working with over
19 million people over the last 22 years, the truth is the truth.
No way
to water it down to make it sound better.
Some
may think it is just their depression returning but who would not feel depressed
if they were still going through Trintellix withdrawal months after stopping the
Trintellix. We can't stress enough; what you do or do not do at this moment in
time is critical for your future. Take your time if at all possible. If you have
brain zaps go buy any omega 3 fish oil, even the wrong omega 3 fish oil will
help somewhat. While you read this you may want to pause and go take a walk.
Look at the trees, the sky or anything off in the distance. Getting your
attention off your mind and body may do wonders. Keep this close to your heart;
There is Hope and There is a Solution. We are speaking directly to YOU.A 30 day
supply of the nutritional supplements will cost you around $80. If you feel it
is worth $80 to take a chance that all of this can go away in a couple of days,
then take that chance. Over the past 22 years many have sent an email to Jim
Harper and said they were not sure what to do about the Trintellix withdrawal.
Even after reading this information. The people that tried something else
generally came back within a few months and were in worse shape than before. We
do not want this to happen to you. But if is; Jim will still be here to assist.
For
safe Benzodiazepine or Trintellix withdrawal, either of these drugs must be
slowly tapered to allow the central nervous system and neurochemistry to safely
normalize.
Choosing to withdrawal from the Trintellix first or the benzodiazepine first
needs to be evaluated. Use Chapter 23, The Science to decide is part of that
equation. Depending on the benzodiazepine you may be taking with the Trintellix,
if you reduce the Trintellix first it may make you go into withdrawal on the
benzodiazepine, even if you did not reduce the benzodiazepine.
There is Hope and There is a Solution
1. FDA drug label Trintellix (vortixetine tablets) Initial US approval 2013 [cited 2022 June 14]
2. Trintellix Drugmaker’s Price Information [cited 2022 June 14]
3. Mahableshwarkar AR, Jacobsen PL, Chen Y, Serenko M, Trivedi MH. A randomized, double-blind, duloxetine-referenced study comparing efficacy and tolerability of 2 fixed doses of vortioxetine in the acute treatment of adults with MDD. Psychopharmacology (Berl). 2015 Jun;232(12):2061-70. doi: 10.1007/s00213-014-3839-0. Epub 2015 Jan 11. PMID: 25575488; PMCID: PMC4432084. [cited 2022 June 14]
4. Josey ES, Tackett RL. St. John’s wort: a new alternative for depression? Int J Clin Pharmacol Ther. 1999 Mar;37(3):111-9. PMID: 10190758. [cited 2022 June 14]
5. Brignone M, Diamand F, Painchault C, Takyar S. Efficacy and tolerability of switching therapy to vortioxetine versus other antidepressants in patients with major depressive disorder. Curr Med Res Opin. 2016;32(2):351-66. doi: 10.1185/03007995.2015.1128404. PMID: 26637048. [cited 2022 June 14]
6. Ansari MA, Abdul HM, Joshi G, Opii WO, Butterfield DA. Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer’s disease. J Nutr Biochem. 2009 Apr;20(4):269-75. doi: 10.1016/j.jnutbio.2008.03.002. Epub 2008 Jul 7. PMID: 18602817; PMCID: PMC2737260. [cited 2022 June 14]
7. Alexander LB, Barber JP, Luborsky L, Crits-Christoph P, Auerbach A. On what bases do patients choose their therapists?. J Psychother Pract Res. 1993;2(2):135-146. [cited 2022 June 14]
8. Neff KD. The Role of Self-Compassion in Development: A Healthier Way to Relate to Oneself. Hum Dev. 2009;52(4):211-214. doi:10.1159/000215071 [cited 2022 June 14]
9. Cacioppo JT, Cacioppo S. Social Relationships and Health: The Toxic Effects of Perceived Social Isolation. Soc Personal Psychol Compass. 2014;8(2):58-72. doi:10.1111/spc3.12087 [cited 2022 June 14]
10. Markey CN, Markey PM. Personality, relationships, and health. J Pers. 2014 Dec;82(6):467-71. doi: 10.1111/jopy.12080. Epub 2014 Feb 8. PMID: 24299020. [cited 2022 June 14]
11. Faragher EB, Cass M, Cooper CL, The relationship between job satisfaction and health: a meta-analysis. Occupational and Environmental Medicine 2005; 62:105-112. [cited 2022 June 14]
12. Gonçalves JP, Lucchetti G, Menezes PR, Vallada H. Religious and spiritual interventions in mental health care: a systematic review and meta-analysis of randomized controlled clinical trials. Psychol Med. 2015 Oct;45(14):2937-49. doi: 10.1017/S0033291715001166. Epub 2015 Jul 23. PMID: 26200715; PMCID: PMC4595860. [cited 2022 June 14]
13. Särkämö T, Soto D. Music listening after stroke: beneficial effects and potential neural mechanisms. Ann N Y Acad Sci. 2012 Apr;1252:266-81. doi: 10.1111/j.1749-6632.2011.06405.x. PMID: 22524369. [[cited 2022 June 14]
14. Ioannidis, J.P. Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials?. Philos Ethics Humanit Med 3, 14 (2008). https://doi.org/10.1186/1747-5341-3-14 [cited 2022 June 14]
15. Irish LA, Kline CE, Gunn HE, Buysse DJ, Hall MH. The role of sleep hygiene in promoting public health: A review of empirical evidence. Sleep Med Rev. 2015;22:23-36. doi:10.1016/j.smrv.2014.10.001 [cited 2022 June 14]
16. Hu Z, Oh S, Ha TW, Hong JT, Oh KW [2018] Sleep-Aids Derived from Natural Products. Biomolecules and Therapeutics, 26(4), 343-349. [cited 2022 June 14]
17. Ljungberg T, Bondza E, Lethin C. Evidence of the Importance of Dietary Habits Regarding Depressive Symptoms and Depression. Int J Environ Res Public Health. 2020;17(5):1616. Published 2020 Mar 2. doi:10.3390/ijerph17051616 [cited 2022 June 14]
18. Musick MA, Wilson J. Volunteering and depression: the role of psychological and social resources in different age groups. Soc Sci Med. 2003 Jan;56(2):259-69. doi: 10.1016/s0277-9536(02)00025-4. PMID: 12473312. [cited 2022 June 14]
19. Wang F, Lee EK, Wu T, Benson H, Fricchione G, Wang W, Yeung AS. The effects of tai chi on depression, anxiety, and psychological well-being: a systematic review and meta-analysis. Int J Behav Med. 2014 Aug;21(4):605-17. doi: 10.1007/s12529-013-9351-9. PMID: 24078491. [cited 2022 June 14]
20. Peluso MA, Guerra de Andrade LH. Physical activity and mental health: the association between exercise and mood. Clinics (Sao Paulo). 2005 Feb;60(1):61-70. doi: 10.1590/s1807-59322005000100012. Epub 2005 Mar 1. PMID: 15838583. [cited 2022 June 14]
21. Schuch FB, Vancampfort D, Firth J, Rosenbaum S, Ward PB, Silva ES, Hallgren M, Ponce De Leon A, Dunn AL, Deslandes AC, Fleck MP, Carvalho AF, Stubbs B. Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies. Am J Psychiatry. 2018 Jul 1;175(7):631-648. doi: 10.1176/appi.ajp.2018.17111194. Epub 2018 Apr 25. PMID: 29690792. [cited 2022 June 14]
22. Purtle J, Nelson KL, Yang Y, Langellier B, Stankov I, Diez Roux AV. Urban-Rural Differences in Older Adult Depression: A Systematic Review and Meta-analysis of Comparative Studies. Am J Prev Med. 2019 Apr;56(4):603-613. doi: 10.1016/j.amepre.2018.11.008. Epub 2019 Feb 16. PMID: 30777704. [cited 2022 June 14]
23. Jensen A, Bonde LO. The use of arts interventions for mental health and wellbeing in health settings. Perspect Public Health. 2018 Jul;138(4):209-214. doi: 10.1177/1757913918772602. Epub 2018 Apr 30. Erratum in: Perspect Public Health. 2018 Sep;138(5):288. PMID: 29708025. [cited 2022 June 14]
24. McManus P, Mant A, Mitchell P, Britt H, Dudley J. Use of antidepressants by general practitioners and psychiatrists in Australia. Aust N Z J Psychiatry. 2003 Apr;37(2):184-9. doi: 10.1046/j.1440-1614.2003.01132.x. PMID: 12656957. [cited 2022 June 14]
25. Guan Y, Wang J, Wu X, Song L, Wang Y, Gong M, Li B. Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2. Brain Res. 2021 Dec 1;1772:147661. doi: 10.1016/j.brainres.2021.147661. Epub 2021 Sep 13. PMID: 34529966. [cited 2022 June 14]
26. von Känel R, Fardad N, Steurer N, Horak N, Hindermann E, Fischer F, Gessler K. Vitamin D Deficiency and Depressive Symptomatology in Psychiatric Patients Hospitalized with a Current Depressive Episode: A Factor Analytic Study. PLoS One. 2015 Sep 23;10(9):e0138550. doi: 10.1371/journal.pone.0138550. PMID: 26397113; PMCID: PMC4580407. [cited 2022 June 14]
27. Szafrański T. Leki ziolowe w leczeniu depresji–aktualny stan wiedzy [Herbal remedies in depression–state of the art]. Psychiatr Pol. 2014 Jan-Feb;48(1):59-73. Polish. PMID: 24946435. [cited 2022 June 14]
28. Janda K, Wojtkowska K, Jakubczyk K, Antoniewicz J, Skonieczna-Żydecka K. Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review. Nutrients. 2020;12(12):3894. Published 2020 Dec 19. doi:10.3390/nu12123894 [cited 2022 June 14]
29. Ng QX, Venkatanarayanan N, Ho CY. Clinical use of Hypericum perforatum (St John’s wort) in depression: A meta-analysis. J Affect Disord. 2017 Mar 1;210:211-221. doi: 10.1016/j.jad.2016.12.048. Epub 2017 Jan 3. PMID: 28064110. [cited 2022 June 14]
30. Martínez-Cengotitabengoa M, González-Pinto A. Nutritional supplements in depressive disorders. Actas Esp Psiquiatr. 2017 Sep;45(Supplement):8-15. Epub 2017 Sep 1. PMID: 29171639. [cited 2022 June 14]
31. Samadian F, Dalili N, Jamalian A. Lifestyle Modifications to Prevent and Control Hypertension. Iran J Kidney Dis. 2016 Sep;10(5):237-263. PMID: 27721223. [cited 2022 June 14]
32. Genuis SJ. Toxic causes of mental illness are overlooked. Neurotoxicology. 2008 Nov;29(6):1147-9. doi: 10.1016/j.neuro.2008.06.005. Epub 2008 Jun 24. PMID: 18621076. [cited 2022 June 14]
33. Genuis SJ. Toxicant exposure and mental health–individual, social, and public health considerations. J Forensic Sci. 2009 Mar;54(2):474-7. doi: 10.1111/j.1556-4029.2008.00973.x. Epub 2009 Jan 31. PMID: 19187449. [cited 2022 June 14]
34. FDA Briefing Document Supplemental Drug Approval Vortioxetine for reatment of Cognitive Dysfunction in Major Depression Disorder published Feb 3 2016 [cited 2022 June 14]
35. Campbell PD, Miller AM, Woesner ME. Bright Light Therapy: Seasonal Affective Disorder and Beyond. Einstein J Biol Med. 2017;32:E13-E25. [cited 2022 June 14]
36. Osadchiy V, Martin CR, Mayer EA. The Gut-Brain Axis and the Microbiome: Mechanisms and Clinical Implications. Clin Gastroenterol Hepatol. 2019 Jan;17(2):322-332. doi: 10.1016/j.cgh.2018.10.002. Epub 2018 Oct 4. PMID: 30292888; PMCID: PMC6999848. [cited 2022 June 14]
37. Wang J, Um P, Dickerman BA, Liu J. Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications. Nutrients. 2018 May 9;10(5):584. doi: 10.3390/nu10050584. PMID: 29747386; PMCID: PMC5986464. [cited 2022 June 14]
38. Yang SY, Fu SH, Chen KL, Hsieh PL, Lin PH. Relationships between depression, health‑related behaviors, and internet addiction in female junior college students. PLoS One. 2019 Aug 9;14(8):e0220784. doi: 10.1371/journal.pone.0220784. PMID: 31398212; PMCID: PMC6688785. [cited 2023 June 5]
39. Kerwick S, Jones R, Mann A, Goldberg D. Mental health care training priorities in general practice. Br J Gen Pract. 1997 Apr;47(417):225-7. PMID: 9196965; PMCID: PMC1312947. [cited 2023 June 5]